Cetrorelix Acetate ≥ 98% CAS No: 120287-85-6
Cetrorelix Acetate ≥ 98% CAS No: 120287-85-6
Cetrorelix Acetate ≥ 98% CAS No: 120287-85-6,Cetrorelix Acetate ≥ 98% ,Cetrorelix Acetate CAS No: 120287-85-6,Cetrorelix Acetate powder,Cetrorelix Acetate
Product Name: Cetrorelix Acetate
Product Purity: ≥ 98%
CAS No: 120287-85-6
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Description
Active Pharmaceutical Ingredient Cetrorelix Acetate Powder Bulk Supply
Premium Gonadotropin-Releasing Hormone (GnRH) Antagonist | Automated SPPS Synthesis Grade for Global Downstream Formulation Lines
Assay ≥ 99.5% (RP-HPLC)
Controlled Endotoxins ≤ 0.5 EU/mg
Full Structure Elucidation (MS/NMR)
CAS 120287-85-6
⚠ REGULATORY COMPLIANCE DIRECTIVE: INDUSTRIAL B2B SUPPLY ONLY
Shaanxi Sunrise Pharmaceutical Co., Ltd. operates strictly as an industrial active raw material and ingredient manufacturer and supplier. This product is a high-potency bulk chemical substance intended exclusively for laboratory scientific research, analytical reference testing, and generic drug formulation development. Shaanxi Sunrise strictly prohibits the distribution or retail of raw materials to private individuals for direct clinical medication or finished therapeutic application.
In the sector of modern bioactive peptide trade, securing high-potency active components demands absolute traceability and structural fidelity. Cetrorelix Acetate supplied by Shaanxi Sunrise Pharmaceutical Co., Ltd. is a synthetic linear decapeptide engineered to function as a potent, immediate-acting gonadotropin-releasing hormone (GnRH) antagonist. Synthesized via standardized automated Solid-Phase Peptide Synthesis (SPPS) loops, we control the amino acid configuration to strictly prevent deletion fragments or isomer contamination.
By binding competitively to the native GnRH receptors on the membranes of pituitary gonadotrope cells, Cetrorelix Acetate completely blocks downstream intracellular signal transduction. This targeted blockade suppresses the pulsatile secretion of endogenous gonadotropins, yielding an immediate, predictable, and fully dose-dependent down-regulation of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) without the counter-productive hormonal flare common to traditional agonists.
"Our deep-vacuum lyophilization parameters create an amorphous powder with excellent hydrophilic solubility, making it optimized for downstream parenterals and competitive binding assays."
Furthermore, our strict in-process control monitors peptide content and counter-ion distribution with intense precision. This chemical discipline prevents batch-to-batch variations, ensuring absolute operational reliability for secondary generic formulation chemists and contract manufacturing organizations (CMOs) operating across highly regulated global regions.
Primary Fields of Application & Research Development
Reproductive Endocrinology
Evaluating follicle development cycles, tracking specific ovarian axis response controls, and formulating advanced pathways to mitigate premature LH surges in scientific reproductive models.
Oncology Investigations
Investigating the targeted anti-proliferative mechanics and receptor binding kinetics on hormone-sensitive malignant cell lines, primarily prostate and specialized mammary tumor models.
Signal Transduction Analysis
Mapping competitive receptor occupation kinetics, measuring GPCR desensitization curves, and analyzing anterior pituitary feedback circuits under intensive chemical pressure.
High-Throughput Bioassays
Serving as a highly stable reference agonist/antagonist agent for validation assays, binding affinity calibration, and screening novel endocrinological compounds.
Audited Release Specifications & Quality Parameters
| Analytical Parameter | Pharmacopoeia Specification Limit | Typical Factory Batch Release | Validated Methodology |
|---|---|---|---|
| Purity (Area Normalization) | CN/USP/EP ≥ 98.0% | ≥ 99.62% | Reversed-Phase HPLC (RP-HPLC) |
| Acetate Content | 9.0% – 15.0% | 11.4% | Ion Chromatography (IC) |
| Bacterial Endotoxins | ≤ 0.50 EU/mg | ≤ 0.15 EU/mg | Kinetic Limulus Amebocyte Lysate (LAL) |
| Water Content (Karl Fischer) | ≤ 5.0% | 2.1% | Titrimetric Volumetric Method |
| Single Maximum Impurity | ≤ 0.50% | 0.18% | HPLC Area Normalization |
| Mass Structural Identity | 1431.04 ± 1.0 Da | Conforms (1431.12 Da) | High-Resolution Mass Spectrometry (HRMS) |
Frequently Asked Questions (Peptide Sourcing Standards)
Can we review complete batch structural verification data before placing bulk orders? ▼
Yes, absolutely. Shaanxi Sunrise accompanies every commercial lot of Cetrorelix Acetate with a full Certificate of Analysis (COA) containing raw liquid chromatography data, mass spectrometry profiling, and moisture tracking datasets to satisfy the stringent audit requirements of international chemical buyers.
Do you support small-scale vial packaging for pilot diagnostics or assay calibration? ▼
We actively support your entire project timeline. Beyond our bulk commercial packages (1 kg to 5 kg sealed aluminum bags), we offer precise downstream down-packaging services, supplying mg-scale sterile borosilicate glass vials (10 mg, 50 mg, 100 mg) to prevent raw substance waste during early pre-clinical modeling.
How do you manage international logistics to prevent peptide chain deformation? ▼
To preserve the decapeptide's delicate spatial configuration, Shaanxi Sunrise deploys validated cold-chain logistics for all overseas freight. Materials are vacuum-sealed with active desiccants and shipped inside heavy-duty isothermal containers packed with dry ice or validated gel packs, ensuring a strict sub-zero environment until final delivery.